By now most people have heard that a Theory of Everything is within reach in the near future, meaning a unified explanation of the physical forces in the universe. Yet "the near future" has stretched out for several decades. This apparent overconfidence and undue optimism points to some serious and as yet unexplained oddities and paradoxes afflicting the flagship theories of science, which are unable, in stark contrast to the prevailing confidence of the past, to explain the vast majority (96%) of the universe. The presence of dark matter and energy, for example, has caused some expected calculations in quantum mechanics to be off by a staggering 120 orders of magnitude.